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Changes in this Edition
Following is a summary of the most significant changes in this
edition of the guidance.
The information contained in Table 3-1 (
Potential Vertebrate Species Related Hazards) is modified as
follows:
° Dace (Rhinichthys spp.) is now listed as having a
potential pesticides and environmental contaminants
hazard;
° Alewife or river herring (Alosa pseudoharengus)
is now listed as having a potential scombrotoxin
(histamine) hazard;
° Wild-caught freshwater salmon (Oncorhynchus
spp., Salmo salar) is no longer listed as having a
potential aquaculture drug hazard, an error in the Second
Edition;
° Mackerel (Scomber scombrus) is no longer listed as
having a potential natural toxin (PSP) hazard.
The information contained in Table 3-3 (
Potential Process Related Hazards) is modified as follows:
° Smoked fish is now listed as having a potential C.
botulinum hazard only when it is reduced oxygen
packaged and distributed or stored refrigerated;
° A number of products are now listed in Table 3-3 as having
potential glass inclusion hazards;
° Dried fish is now listed as having a potential C.
botulinum hazard;
° Fully cooked prepared foods are now listed as having
potential pathogen survival through
pasteurization and pathogen contamination after pasteurization
hazards.
The recommendations in Chapter 4 for the
control of pathogens from the harvest area are changed as
follows for consistency with 1998 and
1999 Interstate Shellfish Sanitation Conference actions:
° Raw consumption warnings on tags of molluscan shellfish
shellstock containers are now recommended
only if the shellstock is intended for raw consump-tion and
the recommended language has been
modified;
° Additional information is included about the control of
Vibrio parahaemolyticus in shellstock
intended for raw consumption, including information about
water sampling for Vibrio parahaemolyticus
performed by Shellfish Control Authorities under certain
conditions;
° Specific controls are now recommended for the control of
Vibrio parahaemolyticus in oyster
shellstock intended for raw consumption if the oysters are
harvested in an area which has been
confirmed as the original source of oysters associated with
two or more V. parahaemolyticus illnesses
in the past three years. The new control strategy example
relies on the following critical limits for the time
from harvest to refrigeration, and is based on the Average
Monthly Maximum Air Temperature
(AMMAT):
-For AMMAT of less than 66°F
(less than 19°C): 36 hours
-For AMMAT of 66°F to 80°F
(19°C to 27°C): 12 hours
-For AMMAT greater than 80°F
(greater than 27°C): 10 hours;
° For the control of Vibrio vulnificus, the critical
limits recommended for the time from harvest to
refrigeration for shellstock intended for raw consumption,
based on Average Monthly Maximum
Water Temperature (AMMWT), are now:
-For AMMWT of less than 65°F
(less than18°C): 36 hours
-For AMMWT of 65 to 74 F (18 to 23 C): 14 hours;
-For AMMWT of greater than 74 to 84 F (greater than 23 to 28
C): 12 hours;
-For AMMWT of greater than 84 F (greater than 28 C): 10 hours;
° For the control of pathogens other than Vibrio
parahaemolyticus
and
Vibrio vulnificus, the
critical limits recommended for the time from harvest to
refrigeration for shellstock intended for
raw consumption are now:
-For AMMAT of less than 66 F
(less than 19 C): 36 hours;
-For AMMAT of 66 to 80 F
(19 to 27 C): 24 hours;
-For AMMAT of greater than 80 F
(greater than 27 C): 20 hours.
The recommendations in Chapter 4 for the
control of pathogens from the harvest area are additionally
changed as follows:
° The information on pathogens in molluscan shellfish is now
more clearly divided into two
categories:
-The control of pathogens of human or animal origin;
-The control of naturally occurring pathogens;
° The recommended goal of pasteurization for the control of
Vibrio vulnificus is now more clearly
defined as the reduction of the pathogen to nondetectable
levels [i. e., less than 3 MPN/ gram, as
defined by the National Shellfish Sanitation Program (NSSP)].
The recommendations in Chapter 5 for the
control of parasites are changed as follows:
° The results of a survey of U. S. gastroenterologists on U.
S. seafood-borne parasitic infections
are now cited;
° The recommended freezing times/ temperatures are now:
-Freezing and storing at -4°F (-20°C) or below
for 7 days (total time); or
-Freezing at -31°F (-35°C) or below until solid
and storing at -31°F (-35°C) or below for 15 hours; or
-Freezing at -31°F (-35°C) or below until solid and storing at
-4°F (-20°C) or below for 24
hours;
° Because of the changes in the recommended critical limits,
the recommended control strategies now
refer only to external temperatures during freezing and to the
length of time that the fish is held at the
appropriate freezer temperature or the length of time that the
fish is held after it is solid frozen,
whichever is appropriate;
° The parasite hazard is no longer considered reasonably
likely to occur if the finished product is
fish eggs that have been removed from the skein and rinsed.
The recommendations in Chapter 6 for the
control of natural toxins are changed as follows:
° PSP in lobster is no longer considered a significant hazard
because the levels found in lobster tomale
are not likely to pose a health hazard unless large quantities
are eaten from a heavily contaminated
area.
The recommendations in Chapter 7 for the
control of scombrotoxin formation are changed as follows:
° Information is now provided about the salt-tolerant and
facultative anaerobic nature of some of the
histamine-forming bacteria, raising concern for scombrotoxin
formation in some salted and smoked
fishery products and in fishery products packed in reduced
oxygen environments (e. g. vacuum
packaging);
° The on-board chilling recommendations are significantly
modified as follows:
-Generally, fish should be placed in ice or in refrigerated
seawater or brine at 40°F (4.4°C)
or less within 12 hours of death, or placed in refrigerated
seawater or brine at 50°F (10°C)
or less within 9 hours of death;
-Fish exposed to air or water temperatures above 83°F
(28.3°C), or large tuna (i. e., above 20 lbs.)
that are eviscerated before on-board chilling, should be
placed in ice (including packing the
belly cavity of large tuna with ice) or in refrigerated
seawater or brine at 40°F (4.4°C) or
less within 6 hours of death;
-Large tuna (i. e., above 20 lbs.) that are not eviscerated
before on-board chilling should
be chilled to an internal temperature of 50°F (10°C) or less
within 6 hours of death;
° It is now recommended that, when refrigerated brine or
seawater is used for chilling fish on the
harvest vessel, the temperature of the cooling media be
monitored and recorded (harvest vessel
control strategy only);
° It is now recommended that the critical limits at receiving
from the harvest vessel include a
requirement that the chilling of fish on the harvest vessel be
continued to bring the internal temperature
of the fish to 40°F (4.4°C) or less (harvest vessel control
strategy only);
° It is now recognized that certain data previously expected
to be recorded by the harvester on harvest
vessel records may, under certain circumstances, be more
efficiently recorded by the primary (first)
processor on receiving records (harvest vessel control
strategy only), such as:
-Method of capture;
-Air and water temperature;
-Method of onboard cooling;
-Estimated date and time of death;
° It is now recognized that, as an alternative to the primary
processor receiving harvest vessel records
that are maintained by the vessel operator, certain harvest
operations may lend themselves to
monitoring and record keeping entirely by the primary
processor. This arrangement is suitable only if
the primary processor has direct knowledge about those aspects
of the harvesting practices that must
be controlled to ensure that the appropriate critical limits
are met. For example, if the harvest vessel
leaves from the processor's facility and returns with the iced
or refrigerated catch to the processor's
facility within the appropriate time limits for on board icing
or refrigeration of the catch, under
certain circumstances it may be possible for the processor to
perform all of the monitoring and record
keeping functions ordinarily performed by the harvester;
° It is now recommended that the critical limits at receiving
from the harvest vessel include a
requirement that fish delivered in less than 12 hours after
death should exhibit evidence that chilling
began on the harvest vessel (e. g. at receipt the internal
temperature of the fish is below ambient air
and water temperature);
° It is now recommended that the date and time of off-loading
be recorded on receiving records
maintained by the primary processor;
° It is no longer recommended that primary (first) processors
check for the adequacy of ice,
refrigerated seawater, refrigerated brine, or other cooling
media at receipt from the harvest vessel;
° It is no longer recommended that secondary processors check
the internal temperature of fish
received from other processors. However, it is now recommended
that the checks for the adequacy of
ice or other cooling media at receiving be verified
periodically by measuring the internal temperature of
the fish to ensure that it is at or below 40°F (4.4°C);
° It is now recommended that the accuracy of time/temperature
data loggers or recorder thermometers
on vehicles delivering fish to secondary processors be checked
on all new suppliers' vehicles and at
least quarterly thereafter;
° The table of approximate safe shelf-life for
scombrotoxin-forming species which was previously
present is replaced with more generalized guidance because the
values contained in the table were
apparently being misused as binding limits;
° The recommended critical limits for storage and processing
are significantly modified as follows:
-For fish that have not been previously frozen: the fish are
not exposed to ambient temperatures
above 40°F (4.4°C) for more than 4 hours, cumulatively, if any
portion of that time is at
temperatures above 70°F (21°C); or the fish are not exposed to
ambient temperatures above 40°F
(4.4°C) for more than 8 hours, cumulatively, as long as no
portion of that time is at temperatures
above 70°F (21°C);
-For fish that have been previously frozen: the fish are not
exposed to ambient temperatures above
40°F (4.4°C) for more than 12 hours, cumulatively, if any
portion of that time is at temperatures
above 70°F (21°C); or the fish are not exposed to ambient
temperatures above 40°F (4.4°C)
for more than 24 hours, cumulatively, as long as no portion of
that time is at temperatures above
70°F (21°C);
° There is no longer a minimum length of frozen storage in the
definition of "previously frozen
product;"
° It is now recommended that ambient air temperature be
monitored at the processing and
packaging critical control points;
° A new concept is introduced to assist in the assessment of
whether the hazard is significant at
receiving by the primary (first) processor: the hazard may not
be significant if the worst case
environmental conditions (i.e. air and water temperatures)
during the harvest season in a particular
region would not permit the formation of histamine during the
time necessary to harvest and
transport the fish to the primary processor;
° The recommendations previously provided for refrigerated
storage are now also recommended
for refrigerated processing;
° For purposes of selecting fish for histamine analysis and
sensory examination it is now
recommended that lots be identified that contain only one
species;
° It is now recommended that the number of fish tested for
internal temperature at receipt by the
primary (first) processor be one per ton for lots of 10 tons
or more, and one per 1000 lbs. for lots
of under 10 tons, as long as at least 12 fish per lot are
examined;
° It is now recommended that no less than 18 fish per lot be
analyzed for histamine at receipt by
the primary (first) processor except where the lot is smaller
than 18 fish (histamine testing control
strategy only). The fish collected for analysis may be
composited for analysis if the critical limit is
reduced accordingly;
° A sample size of 60 fish and a reject level of any fish at
or above 50 ppm histamine is now
recommended as one option for corrective action when the
processing critical limits have been
violated;
° Another option is now provided for corrective action when
the sensory critical limit has been
violated (primary processor):
-Perform histamine analysis on the lot (i.e. fish of common
origin) by analyzing 60 fish (or the
entire lot for lots smaller than 60 fish) and rejecting the
lot if any are found with histamine greater
than or equal to 50 ppm. If found, the lot may be subdivided
and reanalyzed at the same rate,
rejecting those portions where a unit greater than or equal to
50 ppm is found. The fish collected
for analysis may be composited for analysis if the critical
limit is reduced accordingly;
AND
-Perform a sensory examination of all fish in the lot;
° It is now recognized that when refrigerated fish are
transported only short distances (4 hours
or less) from processor to processor, a suitable alternative
to requiring continuous monitoring
during transit may be for the secondary processor to check the
internal temperature of the fish
upon receipt;
° It is no longer recommended that maximum indicating
thermometers be used to monitor ambient
air temperature in storage coolers;
° It is now recommended that high temperature alarms used to
monitor ambient air temperature in
storage coolers be connected to a 24-hour monitoring service.
The recommendations in Chapter 11 for the
control of aquaculture drugs are changed as follows:
° Additional information is now provided about the labeling of
approved conditions of use on
aquaculture drugs;
° Information is now included about the newly approved drug,
chorionic gonadotropin;
° Information is now included about additional approved uses
for formalin solution;
° An additional approved manufacturer of tricaine
methansolfonate is now listed;
° Thiamine hydrochloride is now listed as a low regulatory
priority drug for treatment of thiamine
deficiency in salmonids;
° Discontinued use of the supplier until corrections are made
is now recommended as a corrective
action for all control strategy examples in which aquacultured
fish are received from the producer.
The recommendations in Chapter 12 for the
control of pathogen growth and toxin formation (other than
Clostridium botulinum) as a
result of time/ temperature abuse are changed as follows:
° A third set of recommended critical limits is now provided
for control during processing steps: If the
product is held at internal temperatures both above and below
70°F (21.1°C), exposure times above
50°F (10°C) should ordinarily be limited to 4 hours, as long
as no more than 2 of those hours are
above 70°F (21.1°C);
° Additional information and guidance is now provided to
assist in the development of critical limits
during processing and storage, including:
-Examples of product time/ temperature profiles;
-A recommendation that most microbiologically sensitive
products be stored at or below 40°F
(4.4°C), except where control of nonproteolytic C.
botulinum by refrigeration is necessary, in
which case storage at 38°F (3.3°C) is usually appropriate;
° Additional verification is now recommended, as follows:
-The accuracy of recorder thermometers and other instruments
used to monitor temperature in
transportation cargo areas should be checked on new suppliers'
vehicles and at least quarterly for
each supplier thereafter;
-When visual checks of ice or cooling media are used to
monitor the adequacy of coolant,
the internal temperatures of the fish should be periodically
checked to ensure that the ice or
cooling media is sufficient to maintain product temperatures
at 40°F (4.4°C) or less;
° There is now a specific acknowledgement that frozen product
storage and receipt of frozen
raw materials are not likely CCPs;
° Background information on the pathogens of concern now
indicates that the infective doses of
Listeria monocytogenes and Vibrio parahaemolyticus
are unknown;
° The example HACCP plans in Tables 12-1 and 12-2 are modified
to correct an error in the
Second Edition, in which the cooked crab cooler step was
inadvert-ently included as a CCP in
the Gulf Coast blue crab processing method (Table 12-1),
rather than the East Coast blue crab
processing method (Table 12-2).
° It is now recognized that when refrigerated fishery products
are transported only short
distances (4 hours or less) from processor to processor, a
suitable alternative to requiring
continuous monitoring during transit may be for the secondary
processor to check the internal
temperature of the fish upon receipt;
° It is no longer recommended that maximum indicating
thermometers be used to monitor ambient
air temperature in storage coolers;
° It is now recommended that high temperature alarms used to
monitor ambient air temperature in
storage coolers be connected to a 24-hour monitoring service.
The recommendations in Chapter 13 for the
control of C. botulinum toxin formation are changed
as follows:
° The introductory material is extensively reorga-nized and
revised to provide greater clarity;
° Information is now provided on a recommended minimum oxygen
transmission rate for
oxygen-permeable packages (10,000 cc/m2/24
hrs);
° Fishery products packaged in deep containers from which the
air is expressed are now identified
as presenting a C. botulinum toxin formation hazard;
° Hot smoked product in aerobic packaging is no longer
identified as presenting a C. botulinum toxin
formation hazard sufficient to require preventive controls in
a HACCP plan. However, note that the
Association of Food and Drug Officials recommends a minimum
water phase salt content of 2.5% in
aerobically-packaged smoked fish;
° Controls are no longer recommended specifically for the
control of C. botulinum toxin formation
as a result of time/ temperature abuse during the processing
of unpackaged product. Instead it is
now recommended that the controls recommended for pathogens
other than C. botulinum be
applied as appropriate. The chapter also acknowledges that
C. botulinum toxin formation is
possible in unpackaged or aerobi-cally packaged product, but
that, under those conditions,
it requires the type of severe temperature abuse that is not
reasonably likely to occur in most food
processing environments;
° It is now recognized that when refrigerated fishery products
are transported only short distances
(4 hours or less) from processor to processor, a suitable
alternative to requiring continuous
monitoring during transit may be for the secondary processor
to check the internal temperature
of the fish upon receipt;
° It now states that 20% salt is the level needed to ensure
the safety of a shelf stable product relative to
all pathogens (based on the maximum salt level for growth of
S. aureus), rather than providing the
apparently misleading statement that 10% salt is the level
needed in a shelf stable product for the
control of C. botulinum type A and proteolytic types B
and F;
° It now provides instruction to consult Chapter 12 for
information on refrigerated storage temperature
critical limits suitable for the control of pathogens other
than C. botulinum, rather than providing the
apparently misleading statement that 50°F (10°C) is an
appropriate critical limit for the control of
C. botulinum
type A and proteolytic types B and F. Refrigeration at or below 40°F (4.4°C)
is
recommended for the control of all pathogens;
° Specific guidance is now provided for control of C.
botulinum toxin formation in refrigerated, reduced
oxygen packaged, pasteurized fishery products, including: 1)
those that receive a nonproteolytic
C. botulinum pasteurization process in the final
container; and 2) those that receive a nonproteolytic
C. botulinum cook and are then hot filled into the
final container;
° Specific guidance is now provided for control of C.
botulinum toxin formation in refrigerated, reduced
oxygen packaged pasteurized surimi-based products, including a
recommended control of 2.5% salt in
combination with a pasteurization process in the finished
product container of 185°F (85°C) (internal
temperature) for at least 15 minutes;
° The use of recorder thermometers or digital time/temperature
data loggers throughout distribution and
retail storage and sales is no longer recommended as an
alternative to a second barrier to toxin formation
by C. botulinum type E and nonproteolytic types B and
F;
° It is now acknowledged that, for refrigerated products that
are packaged in oxygen-permeable
packaging, an oxygen-impermeable overwrap may be used to
extend shelf life while the product is
under the control of the processor, as long as the overwrap is
removed before the product leaves the
processor's control;
° It is now recommended that nitrite analysis accompany water
phase salt analysis, as appropriate,
when such analysis is used as the means of monitoring the
brining, dry salting and/or drying steps;
° It is now recommended that the accuracy of time/ temperature
data loggers or recorder thermometers
on vehicles delivering fish to secondary processors be checked
on all new suppliers' vehicles and at least
quarterly thereafter;
° It is no longer recommended that maximum indicating
thermometers be used to monitor ambient air
temperature in storage coolers;
° It is now recommended that high temperature alarms used to
monitor ambient air temperature
in storage coolers be connected to a 24-hour monitoring
service.
The recommendations in Chapter 14 for the
control of pathogen growth and toxin formation as a result of
inadequate drying are changed as
follows:
° Controls are now provided for partial drying of
refrigerated, reduced oxygen packaged foods, where
drying is targeted for the control of C. botulinum
type E and nonproteolytic types B and F. The controls are
designed to ensure that the water activity of the finished
product is below 0.97;
° The importance of packaging in preventing rehydration of
dried products is now noted.
The recommendations in Chapter 16 for the
control of pathogen survival through cooking are changed as
follows:
° The concept of exceptionally lethal cooking processes is
eliminated;
° Information is now provided about the target organism and
degree of destruction for cooking
processes, including recommendations that:
-The target organism should ordinarily be L. monocytogenes;
-The cook should ordinarily provide a 6D process;
° Information is now provided about cooking processes that are
designed to eliminate the spores of
Clostridium botulinum type E and nonproteolytic types B
and F, such as cooking of soups and sauces
that will be reduced oxygen packaged (e. g. vacuum packaged)
and distributed refrigerated. The
information includes the recommendation that such products be
hot filled in a continuous filling system
to minimize the risk of recontamination between cooking and
finished product packaging.
The recommendations in Chapter 17 for the
control of pathogen survival through pasteurization are changed
as follows:
° Information is now provided about the target organism and
degree of destruction for pasteurization
processes, including recommendations that:
-The target organism should ordinarily be Clostridium
botulinum type E and nonproteolytic types
B and F if the product is reduced oxygen packaged (e. g.
vacuum packaged), does not contain
other barriers that are sufficient to prevent growth and toxin
formation by this pathogen, and is stored
or distributed refrigerated (not frozen);
-The target organism should ordinarily be L. monocytogenes
for other products (e. g. frozen products);
-The pasteurization process should ordinarily provide a 6D
reduction in the numbers of the
target pathogen.
The recommendations in Chapter 18 for the
control of pathogen introduction after pasteurization are
changed as follows:
° Information is now provided on hot filling products such as
soups and sauces that are cooked to
eliminate the spores of Clostridium botulinum type E
and nonproteolytic types B and F, and then
reduced oxygen packaged (e. g. vacuum packaged) and then
distributed refrigerated (not frozen).
The minimum recommended hot fill temperature, 185°F (85°C), is
designed to minimize the risk of
recontamination between cooking and finished product
packaging;
° It is now recommended that cooling water flow rate be
controlled when UV treatment is used to
treat container cooling water.
The recommendations in Chapter 19 for the
control of allergens, food intolerance substances and
prohibited food and color additives are
changed as follows:
° Controls similar to those previously recommended for use by
primary processors are now
recommended for use by secondary processors, except that
reliance on raw material labeling or
documents accompanying the raw material shipment (in the case
of unlabeled product) are included
as recommended control strategies when the raw material is
received from another processor;
° Undeclared sulfiting agents are now identified as a
potential hazard in cooked octopus;
° General information is now provided on the control of
allergenic proteins in foods. Controls similar to
those previously recommended to ensure proper labeling for
certain food and color additives are now
recommended if foods that contain allergenic proteins are part
of or are directly added to a fishery
product. Additionally, reference is made to controlling
inad-vertent introduction of allergenic proteins,
because of cross-contact, through a rigorous sanitation
regime, either as part of a prerequisite program
or as part of HACCP itself.
The recommendations in Chapter 20 for the
control of metal inclusion are changed as follows:
° The reference to the point at which FDA's Health Hazard
Evaluation Board has supported regulatory
action is corrected to indicate a metal fragment of between
0.3" [7 mm] and 1.0" [25 mm];
° The recommended corrective actions to regain control over
the operation after metal is detected in
the product now include:
-Locating and correcting the source of the metal fragments;
and
-Making adjustments to the materials, equipment, and/ or
process, as needed, to prevent future
introduction of metal fragments;
° Injection needles and metal ties are now identified as
additional sources of metal fragments in the
processing environment;
° It is now recognized that visually inspecting equipment for
damage or missing parts may only be
feasible with relatively simple equipment, such as band saws,
small orbital blenders, and wire-mesh
belts.
Chapter 21 has been added to provide
guidance on the control of glass inclusion as a result of the use of
glass containers.
The recommendations in the Appendices are
changed as follows:
° The maximum water phase salt level for growth of Bacillus
cereus is now given as 10 percent;
° The maximum water phase salt level for growth of
Staphylococcus aureus is now given as 20 percent;
° The minimum temperature for growth of pathogenic strains of
Escherichia coli is now given as
43.7°F (6.5°C);
° The maximum temperature for growth of Vibrio
parahaemolyticus
is now given as 113.5°F
(45.3°C);
° Maximum cumulative exposure times are now provided for
Bacillus cereus, as follows: 5 days at
temperatures between 39.2 and 43°F (4-6°C); 17 hours at
temperatures between 44 and 50°F
(7-10°C); 6 hours at temperatures between 51 and 70°F
(11-21°C); and 3 hours at temperatures
above 70°F (above 21°C);
° Maximum cumulative exposure times are now provided for
Clostridium perfringens, as follows:
21 days at temperatures between 50 and 54°F (10-12°C); 1 day
at temperatures between 55 and
57°F (13-14°C); 6 hours at temperatures between 58 and 70°F
(15-21°C); and 2 hours at
temperatures above 70°F (above 21°C);
° The maximum cumulative exposure times for proteolytic
Clostridium botulinum are now given as:
11 hours for temperatures between 50 and 70°F (10-21°C); and 2
hours for temperatures above
70°F (above 21°C);
° The maximum cumulative exposure times for nonproteolytic
Clostridium botulinum are now given
as: 7 days for temperatures between 37.9 and 41°F (3.3 -5°C);
2 days for temperatures between 42 and
50°F (6-10°C); 11 hours for temperatures between 51 and 70°F
(11-21°C); and 6 hours for
temperatures above 70°F (above 21°C);
° The maximum cumulative exposure times for Listeria
monocytogenes are now given as:
7 days for temperatures between 31.3 and 41°F (-0.4 -5°C); and
2 days for temperatures between
42 and 50°F (6-10°C);
° The maximum cumulative exposure time for Shigella
spp. is now given as 12 hours for temperatures
between 51 and 70°F (11-21°C);
° Tables of lethal rates and process times for 6D cooks for a
range of internal product temperatures are
now provided for Listeria monocytogenes and
nonproteolytic
Clostridium botulinum type B (Tables
A-3 and A-4, respectively).
° The FDA guideline for hard or sharp objects, found in
Compliance Policy Guide #555.425, is
included in the listing of FDA and EPA guidance levels --
generally 0.3" [7 mm] to 1.0"
[25 mm] in length;
° A listing of the most common food allergens is included
(Appendix 6).
Numerous additional references are now
included in the Bibliography, and a number of the original refer-
ences are corrected.
In addition to using the above listing to direct you to
relevant changes in this guidance, you should
carefully review the chapters that are applicable to your
product and process.
Additional Copies
Single copies of this guidance may be
obtained as long as supplies last from FDA district offices
and from:
U. S. Food and Drug Administration
Office of Seafood
200 C St., S. W.
Washington, D. C. 20204
Phone: 202-418-3133 Fax: 202-418-3196
Multiple copies of this guidance may be obtained from:
Florida Sea Grant
IFAS -Extension Bookstore
University of Florida
P. O. Box 110011
Gainesville, FL 32611-0011
Phone: 352/392-1764 Fax: 352/392-2628
Credit card orders only, phone: 1-800/226-1764
http://ifasbooks.ufl.edu/merchant2/merchant.mv
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